INTRODUCING RADIANCE 330 PROTON THERAPY Solution

The Radiance 330 Proton Therapy System Series offers a comprehensive range of proton therapy solutions, enabling healthcare providers to develop single or multi-room capabilities within or adjacent to existing radiation oncology departments, seamlessly integrating proton therapy as an extension of radiation oncology.

Featuring a modular design, the Radiance 330 utilizes advanced pencil beam scanning technology and a compact synchrotron particle accelerator, delivering a clinical treatment energy range of 70 MeV to 250 MeV with upgradeable capacity up to 330 MeV for future proton imaging deployment. As one of the fastest-evolving fields in healthcare, radiation therapy demands continuous technological advancements, and ProTom is uniquely equipped to meet these challenges, ensuring faster time-to-market and quicker access for patients in need.

The Radiance 330® has the smallest synchrotron footprint in the market. Synchrotrons have low secondary neutrons and scatter radiation, which lowers the risk of unnecessary and unwanted radiation to the patient and facility.

The Radiance 330® synchrotron design allows for dynamic modulation of proton beam energy and intensity in three dimensions utilizing Radiance 330®’s Fidelity Beam™ Scanning System. This allows precise positioning of the beam and deposition of dose through the use of computer-controlled scanning magnets. This ability to adjust intensity and energy in real-time, when combined with the system’s active scanning delivery capabilities, enables the system to deliver three-dimensional, intensity-modulated proton therapy (IMPT). This enhanced level of dosimetric precision (and reduction in dose to normal tissue) allows clinicians to deliver higher doses to target volumes, increasing the probability for tumor control; this also enables clinicians to target smaller and/or difficult-to-reach tumors near sensitive organs.

Because synchrotron technology produces the energy required, no degrading of the beam is required to alter energy. Therefore, the synchrotron is the more energy efficient choice of the two particle accelerators. Add to that the cost savings of decreased shielding and an easier installation, and the synchrotron becomes the top choice for proton therapy facilities.

The Radiance 330® delivers the most advanced form of proton therapy treatment with the

precision of pencil beam scanning.

Pencil beam scanning delivers superior dose sculpting and higher beam efficiencies than other methods of proton beam delivery. This reduces unwanted side effects, improves long-term

outcomes for patients, and improves the patient’s quality of life.

FIDELITY BEAM SCANNING

The Radiance 330® is equipped with ProTom’s Fidelity Beam™ Scanning System, which uses matrix spot scanning. This type of scanning accurately “paints” a tumor with the prescribed dose using beam energy variations to control penetration depth and magnetic steering to guide lateral dose deposition.

CLEAN BEAM

The Radiance 330® produces far fewer neutrons than cyclotron-based treatment.

The physical characteristics of a synchrotron ensure that protons lost during production are only low energy protons, either during injection or after the beam has been decelerated. The lower energy protons are less able to produce induced secondary radiation activity. This means patients, staff, ancillary equipment and the building are exposed to fewer neutrons, less shielding is required, and no equipment cool-off period is needed before entering the vault for routine maintenance.

SUPERIOR, INTEGRATED IMAGING.

It’s designed to interface with in-room imaging solutions, such as computed tomography or cone beam computed tomography. It’s also equipped with orthogonal imaging, including image-registration software, which generates a six degree of freedom patient-alignment correction vector.

In addition to supporting ProTom’s own 2D X-Ray solution, the Radiance 330® has the ability to adapt to a number of off-the-shelf imaging products.

The lightweight, compact, modular design of the Radiance 330® eliminates the need for heavy equipment in the delivery, construction, and installation phases. This, along with the ability to install the Radiance 330® above-grade or within existing space, significantly reduces costs.

Developing proton therapy capability with the Radiance 330® represents an economically viable project, dramatically simplifying construction and installation. The patented and proven design of the compact synchrotron allows for accelerator interior vault space of approximately 20’ x 30’ and requires 30 - 50% less radiation shielding than most other systems on the market today. The

lighter-weight, compact technology makes installation easier and simpler, even in the most space-constrained environment. The largest equipment component requires no hatch, special crane, transport, or reinforced roadways and is easily moved-in through typical freight or staff entrances. A simpler project with lower construction and equipment costs is easier to implement, translating to faster time-to-market and faster time to patients-in-need.

The Radiance 330® runs more efficiently, generates less heat, and consumes far less electricity than most other proton therapy systems, translating to enormous savings on lifetime operational costs. Furthermore, the system’s smaller scale makes it possible to add proton therapy as an

extension to an existing cancer treatment program/center, saving on the cost of land and avoiding the expense of duplicating facilities, ancillary equipment, and personnel.

The design of the Radiance 330® features an intuitive and user-friendly interface. Experienced users of a variety of proton beam therapy systems were consulted in the design of the control system. That empirical information was used to integrate workflow guidance into the operator controls, enabling radiation therapists to spend less time interacting with the equipment and more time focusing on the patient.

The ProTom-designed screens have uncluttered, organized display panels, with integrated touch screen technology employed inside and outside the treatment room. Outside the treatment room, the Treatment Control System screen provides the radiation therapist with a single-screen view of all required patient information including plan information, treatment fields, room coordinates, digitally reconstructed radiographs, beam status, and a “beam-on” dose monitor.

Inside the treatment room the control touch-screen provides a unique workflow-driven view. This user interface functions not only as a control and status display for the equipment, but also as a workflow guide for the radiation therapist. As the different function “buttons” on the touch-screen are selected, the therapist is guided through the workflow of treating a patient, including imaging and robotic-patient positioning with six degrees of freedom. Customizable, pre-programmed movements for both imaging and treatment workflows are available. Additionally, multiple programmed destination sequences can be saved for clinical use, for physics quality assurance checks, and for preventive maintenance routines.

INTRODUCING RADIANCE 330 PROTON THERAPY Solution

SYNCHROTRON TECHNOLOGY